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Article

Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton.

EMBO reports - 1 Jul 2005

Lauritzen Inger, Chemin Jean, Honoré Eric, Jodar Martine, Guy Nicolas, Lazdunski Michel, Jane Patel Amanda

Abstract excerpt

TREK-1 (KCNK2) is a K(2P) channel that is highly expressed in fetal neurons. This K(+) channel is opened by a variety of stimuli, including membrane stretch and cellular lipids. Here, we show that the expression of TREK-1 markedly alters the cytoskeletal network and induces the formation of actin- and ezrin-rich membrane protrusions. The genetic inactivation of TREK-1 significantly alters the growth cone...

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Share to Actin Cytoskeleton
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 15976821
DOI: 10.1038/sj.embor.7400449
PMCID: PMC1369110

Genes

KCNK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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