Article

Knock-out of Tpm4.2/actin filaments alters neuronal signaling, neurite outgrowth and behavioral phenotypes in mice

2025-04-10

Abstract excerpt

Tropomyosins (Tpm) are master regulators of actin dynamics through forming co-polymers with filamentous actin. Despite the well-understood function of muscle Tpms in the contractile apparatus of muscle cells, much less is known about the diverse physiological function of cytoplasmic Tpms in eukaryotic cells. Here, we investigated the role of the Tpm4.2 isoform in neuronal processes including signaling, neurite out...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a758f30c-0683-5714-a1bc-a25f55c0bd9f
DOI: 10.1101/2025.04.10.648285

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Knock-out of Tpm4.2/actin filaments alters neuronal signaling, neurite outgrowth and behavioral phenotypes in miceDOI 10.1101/2025.04.10.648285Read

Drosophila twinfilin is required for cell migration and synaptic endocytosis.Semantic proximity Read

Plectin dysfunction in neurons leads to tau accumulation on microtubules affecting neuritogenesis, organelle trafficking, pain sensitivity and memorySemantic proximity Read

Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance.Semantic proximity Read

Muscle cofilin alters neuromuscular junction postsynaptic development to strengthen functional neurotransmissionSemantic proximity Read

Dynamic microtubules drive circuit rewiring in the absence of neurite remodeling.Semantic proximity Read

Neuronal actin cytoskeleton gain of function in the human brainSemantic proximity Read

Non-muscle myosin II in disease: mechanisms and therapeutic opportunitiesSemantic proximity Read

Myosin Va Brain-Specific Mutation Alters Mouse Behavior and Disrupts Hippocampal SynapsesSemantic proximity Read

Mutations in KPTN cause macrocephaly, neurodevelopmental delay, and seizures.Semantic proximity Read

Constitutive Inactivation of the PRRT2 Gene Alters Short-Term Synaptic Plasticity and Promotes Network Hyperexcitability in Hippocampal NeuronsSemantic proximity Read

Multiple CaMKII Binding Modes to the Actin Cytoskeleton Revealed by Single-Molecule Imaging.Semantic proximity Read

CDKL5’s role in microtubule-based transport and cognitive functionSemantic proximity Read