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Article

Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

27 Sept 2021

Abstract excerpt

Keratinocytes, the predominant cell type of the epidermis, migrate to reinstate the epithelial barrier during wound healing. Mechanical cues are known to regulate keratinocyte re-epithelialization and wound healing; however, the underlying molecular transducers and biophysical mechanisms remain elusive. Here, we show through molecular, cellular, and organismal studies that the mechanically activated ion channel...

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PMID: 34569935
DOI: 10.7554/elife.65415

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