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Article

Genetic deletion or antibody blockade of alpha1beta1 integrin induces a stable plaque phenotype in ApoE-/- mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2005

Schapira Kitty, Lutgens Esther, de Fougerolles Antonin, Sprague Andrew, Roemen Anouk, Gardner Humphrey, Koteliansky Victor, Daemen Mat, Heeneman Sylvia

Abstract excerpt

OBJECTIVE: Adhesive interactions between cells and the extracellular matrix play an important role in inflammatory diseases like atherosclerosis. We investigated the role of the collagen-binding integrin alpha1beta1 in atherosclerosis. METHODS AND RESULTS: ApoE-/- mice were alpha1-deficient or received early or delayed anti-alpha1 antibody treatment. Deficiency in alpha1 integrin reduced the area of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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PMID: 15976328
DOI: 10.1161/01.ATV.0000174807.90292.2f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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