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Article

Integrin affinity modulation critically regulates atherogenic endothelial activation in vitro and in vivo.

Matrix biology : journal of the International Society for Matrix Biology - 1 Feb 2021

Al-Yafeai Zaki, Pearson Brenna H, Peretik Jonette M, Cockerham Elizabeth D, Reeves Kaylea A, Bhattarai Umesh, Wang Dongdong, Petrich Brian G, Orr A Wayne

Abstract excerpt

While vital to platelet and leukocyte adhesion, the role of integrin affinity modulation in adherent cells remains controversial. In endothelial cells, atheroprone hemodynamics and oxidized lipoproteins drive an increase in the high affinity conformation of α5β1 integrins in endothelial cells in vitro, and α5β1 integrin inhibitors reduce proinflammatory endothelial activation to these stimuli in vitro and in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33157226
DOI: 10.1016/j.matbio.2020.10.006
PMCID: PMC7902378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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