Article
The abruptex mutations of notch disrupt the establishment of proneural clusters in Drosophila.
Developmental biology - 1 Dec 1999
Brennan K, Tateson R, Lieber T, Couso J P, Zecchini V, Arias A M
Abstract excerpt
The receptor encoded by the Notch gene plays a central role in preventing cells from making decisions about their fates until appropriate signals are present. This function of Notch requires the product of the Suppressor of Hairless gene. Loss of either Notch or Suppressor of Hairless function results in cells making premature and incorrect cell fate decisions, whilst increases in Notch signalling prevent cells...
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