Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neural precursor-specific expression of multiple Drosophila genes is driven by dual enhancer modules with overlapping function.

Proceedings of the National Academy of Sciences of the United States of America - 2 Dec 2014

Miller Steven W, Rebeiz Mark, Atanasov Jenny E, Posakony James W

Abstract excerpt

Transcriptional cis-regulatory modules (CRMs), or enhancers, are responsible for directing gene expression in specific territories and cell types during development. In some instances, the same gene may be served by two or more enhancers with similar specificities. Here we show that the utilization of dual, or "shadow", enhancers is a common feature of genes that are active specifically in neural precursor (NP)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Microscopy, Confocal

Share to Neural Stem Cells

Share to Neurogenesis

Share to Sense Organs

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 25404315
DOI: 10.1073/pnas.1415308111
PMCID: PMC4260543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neural precursor-specific expression of multiple Drosophila genes is driven by dual enhancer modules with overlapping function.PMID 25404315Read ↗

Two modes of recruitment of E(spl) repressors onto target genes.Semantic proximity Read ↗

Persistent expression of genes of the enhancer of split complex suppresses neural development in Drosophila.Semantic proximity Read ↗

A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression.Semantic proximity Read ↗

Characterization of the proneural gene regulatory network during mouse telencephalon development.Semantic proximity Read ↗

Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund.Semantic proximity Read ↗

Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless.Semantic proximity Read ↗

Robust target gene discovery through transcriptome perturbations and genome-wide enhancer predictions in Drosophila uncovers a regulatory basis for sensory specification.Semantic proximity Read ↗

Analysis of an even-skipped rescue transgene reveals both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradients.Semantic proximity Read ↗

The Notch targets Esr1 and Esr10 are differentially regulated in Xenopus neural precursors.Semantic proximity Read ↗

Drosophila C-terminal binding protein, dCtBP is required for sensory organ prepattern and sharpens proneural transcriptional activity of the GATA factor Pnr.Semantic proximity Read ↗

The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors.Semantic proximity Read ↗

Independent roles of the dachshund and eyes absent genes in BMP signaling, axon pathfinding and neuronal specification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.