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Article

The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes.

Cell - 14 Jan 1994

Hinz U, Giebel B, Campos-Ortega J A

Abstract excerpt

The development of most epidermal sensory organs in Drosophila is controlled by achaete and scute, two of the genes of the achaete-scute complex (AS-C). The genes of the AS-C encode members of the basic-helix-loop-helix (bHLH) class of transcriptional regulators, and their activity defines proneural cell clusters in the imaginal discs from which sensory organ mother cells are singled out by a process of lateral...

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PMID: 8287481
DOI: 10.1016/0092-8674(94)90174-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes.PMID 8287481Read ↗

The complex tale of the achaete-scute complex: a paradigmatic case in the analysis of gene organization and function during development.Semantic proximity Read ↗

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Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc.Semantic proximity Read ↗

Cis-regulation of achaete and scute: shared enhancer-like elements drive their coexpression in proneural clusters of the imaginal discs.Semantic proximity Read ↗

The genetics of the Drosophila achaete-scute gene complex: a historical appraisal.Semantic proximity Read ↗

Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing.Semantic proximity Read ↗

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The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein.Semantic proximity Read ↗

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