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Article

Su(H)-independent activity of hairless during mechano-sensory organ formation in Drosophila.

Mechanisms of development - 1 Jun 2000

Nagel A C, Maier D, Preiss A

Abstract excerpt

Formation of mechano-sensory organs in Drosophila involves the selection of neural precursor cells (SOPs) mediated by the classical Notch pathway in the process of lateral inhibition. Here we show that the subsequent cell type specifications rely on distinct subsets of Notch signaling components. Whereas E(spl) bHLH genes implement SOP selection, they are not required for later decisions. Most remarkably, the...

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Identifiers

PMID: 10842054
DOI: 10.1016/s0925-4773(00)00319-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Su(H)-independent activity of hairless during mechano-sensory organ formation in Drosophila.PMID 10842054Read ↗

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Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development.Semantic proximity Read ↗

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Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway.Semantic proximity Read ↗

Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc.Semantic proximity Read ↗

The Notch ligand Jagged1 is required for inner ear sensory development.Semantic proximity Read ↗

Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.Semantic proximity Read ↗

Hairless is required for the development of adult sensory organ precursor cells in Drosophila.Semantic proximity Read ↗

The activity of Drosophila Hairless is required in pupae but not in embryos to inhibit Notch signal transduction.Semantic proximity Read ↗

Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development.Semantic proximity Read ↗

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.Semantic proximity Read ↗

Notch signaling during cell fate determination in the inner ear.Semantic proximity Read ↗

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