Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway.

Developmental biology - 1 Dec 1995

Bang A G, Bailey A M, Posakony J W

Abstract excerpt

In Drosophila imaginal discs, the function of the Hairless (H) gene is required at multiple steps during the development of adult sensory organs. Here we report the results of a series of experiments designed to investigate the in vivo role of H in sensory organ precursor (SOP) cell specification. We show that the proneural cluster pattern of proneural gene expression and of transcriptional activation by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to Drosophila Proteins
Share to Membrane Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Promoter Regions, Genetic

Share to Proteins

Share to Signal Transduction

Share to Transcription Factors

Source

Identifiers

PMID: 8612965
DOI: 10.1006/dbio.1995.8033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway.PMID 8612965Read ↗

Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development.Semantic proximity Read ↗

A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila.Semantic proximity Read ↗

Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless.Semantic proximity Read ↗

Hairless is required for the development of adult sensory organ precursor cells in Drosophila.Semantic proximity Read ↗

Su(H)-independent activity of hairless during mechano-sensory organ formation in Drosophila.Semantic proximity Read ↗

Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc.Semantic proximity Read ↗

Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing.Semantic proximity Read ↗

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete.Semantic proximity Read ↗

The abruptex mutations of notch disrupt the establishment of proneural clusters in Drosophila.Semantic proximity Read ↗

Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis.Semantic proximity Read ↗

Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless.Semantic proximity Read ↗

The activity of Drosophila Hairless is required in pupae but not in embryos to inhibit Notch signal transduction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.