Article
CD14 C-159T and early infection with Pseudomonas aeruginosa in children with cystic fibrosis.
Respiratory research - 23 Jun 2005
Martin A C, Laing I A, Zhang G, Brennan S, Winfield K, Sly P D, Stick S M, Goldblatt J, LeSouef P N
Abstract excerpt
Early acquisition of Pseudomonas aeruginosa is associated with a poorer prognosis in patients with cystic fibrosis. We investigated whether polymorphisms in CD14, the lipopolysaccharide receptor, increase the risk of early infection. Forty-five children with cystic fibrosis were investigated with annual bronchoalveolar lavage (BAL) and plasma sCD14 levels. Plasma sCD14 levels were significantly lower in children...
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