Article
CD14 expression in the first 24h of sepsis: effect of -260C>T CD14 SNP.
Immunological investigations - 1 Jan 2008
de Aguiar Bibiana Butkus, Girardi Ingrid, Paskulin Diego D'Avila, de Franca Everaldo, Dornelles Cláudia, Dias Fernando Suparregui, Bonorino Cristina, Alho Clarice Sampaio
Abstract excerpt
Sepsis is defined as systemic inflammation caused by infection. The membrane bound CD14 (mCD14) or the soluble form (sCD14) play a crucial role facing Gram-negative and Gram-positive sepsis since they are pattern recognition receptors of the innate immune response enabling cells to produce inflammatory cytokines against bacterial infections. A -260C>T single nucleotide polymorphism (SNP) was detected in the...
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