Article
Association between CD14 polymorphisms and serum soluble CD14 levels: effect of atopy and endotoxin inhalation.
The Journal of allergy and clinical immunology - 1 Feb 2008
Levan Tricia D, Michel Olivier, Dentener Mieke, Thorn Jörgen, Vertongen Francoise, Beijer Lena, Martinez Fernando D
Abstract excerpt
BACKGROUND: A prerequisite for activation of the innate immune response by endotoxin is its binding to CD14. OBJECTIVE: The aim of this study was to evaluate the role of CD14 polymorphisms, atopy, and inhaled endotoxin in modulating serum CD14 levels. METHODS: Healthy volunteers (n = 88) were genotyped for CD14 polymorphisms at the -1619, -1359, and -159 loci, relative to the transcription start site. Subjects...
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