Article
CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation?
The Journal of allergy and clinical immunology - 1 Jun 2010
Munthe-Kaas Monica Cheng, Torjussen Tale Maehre, Gervin Kristina, Lødrup Carlsen Karin C, Carlsen Kai Håkon, Granum Berit, Hjorthaug Hanne Sagsveen, Undlien Dag, Lyle Robert
Abstract excerpt
BACKGROUND: CD14 is a pattern-recognition receptor for environmental LPS, and engagement of the CD14-LPS complex activates innate host defense mechanisms. Single nucleotide polymorphisms (SNPs) in the CD14 gene have been associated with soluble CD14 (sCD14) levels, but inconsistencies between studies suggest the presence of regulatory mechanisms hitherto not well understood. OBJECTIVE: We sought to investigate...
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