Article
EphB receptor activity suppresses colorectal cancer progression.
Nature - 23 Jun 2005
Batlle Eduard, Bacani Julinor, Begthel Harry, Jonkheer Suzanne, Jonkeer Suzanne, Gregorieff Alexander, van de Born Maaike, Malats Núria, Sancho Elena, Boon Elles, Pawson Tony, Gallinger Steven, Pals Steven, Clevers Hans
Abstract excerpt
Most sporadic colorectal cancers are initiated by activating Wnt pathway mutations, characterized by the stabilization of beta-catenin and constitutive transcription by the beta-catenin/T cell factor-4 (Tcf-4) complex. EphB guidance receptors are Tcf4 target genes that control intestinal epithelial architecture through repulsive interactions with Ephrin-B ligands. Here we show that, although Wnt signalling...
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