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Article

EphB6 overexpression and Apc mutation together promote colorectal cancer.

Oncotarget - 24 May 2016

Xu Dan, Yuan Liang, Liu Xin, Li Mingqi, Zhang Fubin, Gu Xin Yue, Zhang Dongwei, Yang Youlin, Cui Binbin, Tong Jinxue, Zhou Jin, Yu Zhiwei

Abstract excerpt

The erythropoietin-producing hepatocyte (Eph) family tyrosine kinases play important roles in tumorigenesis and cancer aggression. In this study, we investigated the role of EphB6 in oncogenic transformation of colorectal epithelial cells in vitro and in vivo. EphB6 is upregulated in human colorectal cancer (CRC) tissues as compared to normal tissues, and its overexpression promotes proliferation, migration and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27145271
DOI: 10.18632/oncotarget.9080
PMCID: PMC5058743

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