Article
Genetic and epigenetic analysis of the EPHB2 gene in gastric cancers.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Feb 2007
Song Jae Hwi, Kim Chang Jae, Cho Yong Gu, Kwak Hyun Jung, Nam Suk Woo, Yoo Nam Jin, Lee Jung Young, Park Won Sang
Abstract excerpt
EPHB2 is a member of the Eph receptor tyrosine kinase family and a direct transcriptional target of beta-catenin/TCF. EPHB2 plays an important role in maintaining the correct positioning of the proliferative compartment in the crypt-villous axis. A loss of EPHB2 expression has been observed in human tumors, particularly in colonic adenomas and carcinomas. A search was made for mutations at the A9 tract in exon...
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