Article
Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients.
Thorax - 1 Oct 2005
Ward C, Forrest I A, Murphy D M, Johnson G E, Robertson H, Cawston T E, Fisher A J, Dark J H, Lordan J L, Kirby J A, Corris P A
Abstract excerpt
BACKGROUND: Obliterative bronchiolitis in chronic rejection of lung allografts is characterised by airway epithelial damage and fibrosis. The process whereby normal epithelium is lost and replaced by fibroblastic scar tissue is poorly understood, but recent findings suggest that epithelial cells can become fibroblasts through epithelial-mesenchymal transition (EMT). It is hypothesised that EMT occurs in lung...
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