Article
Fibroblast phenotypes and their activity are changed in the wound healing process after lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Aug 2011
Andersson-Sjöland Annika, Thiman Lena, Nihlberg Kristian, Hallgren Oskar, Rolandsson Sara, Skog Ingrid, Mared Lena, Hansson Lennart, Eriksson Leif, Bjermer Leif, Westergren-Thorsson Gunilla
Abstract excerpt
BACKGROUND: Lung transplantation (LTx) is established as a life-saving treatment in end-stage lung disease. However, long-term survival is hampered by the development of chronic rejection, almost synonymous with bronchiolitis obliterans syndrome (BOS). The rejection is characterized by deposition of extracellular matrix in small airways. Fibroblasts/myofibroblasts are the main producers of extracellular matrix...
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