Article
Cigarette smoke extract induces a phenotypic shift in epithelial cells; involvement of HIF1α in mesenchymal transition.
PloS one - 1 Jan 2014
Eurlings Irene M J, Reynaert Niki L, van den Beucken Twan, Gosker Harry R, de Theije C C, Verhamme Fien M, Bracke Ken R, Wouters Emiel F M, Dentener Mieke A
Abstract excerpt
In COPD, matrix remodeling contributes to airflow limitation. Recent evidence suggests that next to fibroblasts, the process of epithelial-mesenchymal transition can contribute to matrix remodeling. CSE has been shown to induce EMT in lung epithelial cells, but the signaling mechanisms involved are largely unknown and subject of this study. EMT was assessed in A549 and BEAS2B cells stimulated with CSE by qPCR,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.