Article
Basal cells of the human airways acquire mesenchymal traits in idiopathic pulmonary fibrosis and in culture.
Laboratory investigation; a journal of technical methods and pathology - 1 Dec 2015
Jonsdottir Hulda R, Arason Ari J, Palsson Ragnar, Franzdottir Sigridur R, Gudbjartsson Tomas, Isaksson Helgi J, Gudmundsson Gunnar, Gudjonsson Thorarinn, Magnusson Magnus K
Abstract excerpt
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with high morbidity and mortality. The cellular source of the fibrotic process is currently under debate with one suggested mechanism being epithelial-to-mesenchymal transition (EMT) in the alveolar region. In this study, we show that airway epithelium overlying fibroblastic foci in IPF contains a layer of p63-positive basal cells...
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