Article
Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition.
The European respiratory journal - 1 May 2015
Gohy Sophie T, Hupin Cloé, Fregimilicka Chantal, Detry Bruno R, Bouzin Caroline, Gaide Chevronay Héloïse, Lecocq Marylène, Weynand Birgit, Ladjemi Maha Z, Pierreux Christophe E, Birembaut Philippe, Polette Myriam, Pilette Charles
Abstract excerpt
In chronic obstructive pulmonary disease (COPD), epithelial changes and subepithelial fibrosis are salient features in conducting airways. Epithelial-to-mesenchymal transition (EMT) has been recently suggested in COPD, but the mechanisms and relationship to peribronchial fibrosis remain unclear. We hypothesised that de-differentiation of the COPD respiratory epithelium through EMT could participate in airway...
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