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Article

Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis.

The American journal of pathology - 1 May 2005

Willis Brigham C, Liebler Janice M, Luby-Phelps Katherine, Nicholson Andrew G, Crandall Edward D, du Bois Roland M, Borok Zea

Abstract excerpt

The hallmark of idiopathic pulmonary fibrosis (IPF) is the myofibroblast, the cellular origin of which in the lung is unknown. We hypothesized that alveolar epithelial cells (AECs) may serve as a source of myofibroblasts through epithelial-mesenchymal transition (EMT). Effects of chronic exposure to transforming growth factor (TGF)-beta1 on the phenotype of isolated rat AECs in primary culture and a rat type II...

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Identifiers

PMID: 15855634
DOI: 10.1016/s0002-9440(10)62351-6
PMCID: PMC1606388

Genes

AQP5
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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