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Article

NF-κB activation and potentiation of proinflammatory responses by the <i>Helicobacter pylori</i> CagA protein

21 Jun 2005

Abstract excerpt

The Helicobacter pylori immunodominant protein, CagA, is associated with severe gastritis and carcinoma. Injection of CagA into gastric epithelial cells by type IV secretion leads to actin-cytoskeletal rearrangements and cell scattering. CagA has been reported to have no role in the induction of transcription factor NF-kappaB and IL-8, which are crucial determinants for chronic inflammation. Here, we provide...

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PMID: 15972330
DOI: 10.1073/pnas.0409873102

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