Article
Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1998
Sharma S A, Tummuru M K, Blaser M J, Kerr L D
Abstract excerpt
In vivo, gastric infection with Helicobacter pylori leads to substantial production of the inflammatory cytokines IL-1, IL-6, TNF-alpha, and IL-8. H. pylori strains that contain the cag pathogenicity island (cag+) and are associated with ulceration and gastric carcinoma induce greater cytokine pr...
Topics
- Bacterial Proteins
- CCAAT-Enhancer-Binding Proteins
- DNA
- DNA-Binding Proteins
- Epithelial Cells
- Gastric Mucosa
- Gene Expression Regulation
- Helicobacter pylori
- Humans
- Interleukin-6
- Interleukin-8
- NF-kappa B
- Nuclear Proteins
- Phenotype
- Promoter Regions, Genetic
- Protein Binding
- Stomach Neoplasms
- Transcription, Genetic