Article
IV.Helicobacter pyloristrain-specific activation of signal transduction cascades related to gastric inflammation
1 Apr 2001
Abstract excerpt
Helicobacter pylori strains that possess the cag pathogenicity island induce more severe gastritis and augment the risk of developing peptic ulcer disease and distal gastric cancer. A specific mechanism by which cag(+) strains may enhance gastritis is strain-selective regulation of interleukin (IL)-8 production. On contact with gastric epithelial cells, H. pylori activates multiple signal transduction cascades...
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