Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair.

doi:10.1038/s41467-018-04327-0

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Article

Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair.

Nature communications - 23 May 2018

Seol Ja-Hwan, Holland Cory, Li Xiaolei, Kim Christopher, Li Fuyang, Medina-Rivera Melisa, Eichmiller Robin, Gallardo Ignacio F, Finkelstein Ilya J, Hasty Paul, Shim Eun Yong, Surtees Jennifer A, Lee Sang Eun

Abstract excerpt

Yeast Rad1-Rad10 (XPF-ERCC1 in mammals) incises UV, oxidation, and cross-linking agent-induced DNA lesions, and contributes to multiple DNA repair pathways. To determine how Rad1-Rad10 catalyzes inter-strand crosslink repair (ICLR), we examined sensitivity to ICLs from yeast deleted for SAW1 and SLX4, which encode proteins that interact physically with Rad1-Rad10 and bind stalled replication forks. Saw1, Slx1,...

Topics

Animals
CHO Cells
Cell Cycle
Cricetulus
Cross-Linking Reagents
DNA Damage
DNA Repair
DNA Repair Enzymes
DNA-Binding Proteins
Endonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intravital Microscopy

Mutagenesis, Site-Directed

Mutation

Saccharomyces cerevisiae Proteins

Single-Strand Specific DNA and RNA Endonucleases

Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 29795289
DOI: 10.1038/s41467-018-04327-0
PMCID: PMC5966407

Genes

ERCC1
SLX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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