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Article

The yeast Xrs2 complex functions in S phase checkpoint regulation.

Genes & development - 1 Sept 2001

D'Amours D, Jackson S P

Abstract excerpt

The Nbs1 complex is an evolutionarily conserved multisubunit nuclease composed of the Mre11, Rad50, and Nbs1 proteins. Hypomorphic mutations in the NBS1 or MRE11 genes in humans result in conditions characterized by DNA damage sensitivity, cell cycle checkpoint deficiency, and high cancer incidence. The equivalent complex in the yeast Saccharomyces cerevisiae (Xrs2p complex) has been implicated in DNA...

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Identifiers

PMID: 11544181
DOI: 10.1101/gad.208701
PMCID: PMC312768

Genes

ATM
MRE11

Provenance

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