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The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint.

Genetics - 1 Apr 2010

Willis Nicholas, Rhind Nicholas

Abstract excerpt

The Mre11-Rad50-Nbs1 (MRN) heterotrimer plays various and complex roles in DNA damage repair and checkpoint signaling. Its role in activating Ataxia-Telangiectasia Mutated (ATM), the central checkpoint kinase in the metazoan double-strand break response, has been well studied. However, its function in the checkpoint independent of ATM activation, as well as functions that are completely checkpoint independent,...

Topics

Checkpoint Kinase 2
Chromosomal Proteins, Non-Histone
DNA Damage
DNA Replication
Exodeoxyribonucleases
Kinetics
Mutation
Protein Serine-Threonine Kinases
S Phase
Schizosaccharomyces
Schizosaccharomyces pombe Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

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Open in PubMed Open full text

Identifiers

PMID: 20065069
DOI: 10.1534/genetics.109.113019
PMCID: PMC2865925

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint.PMID 20065069Read ↗

The role of MRN in the S-phase DNA damage checkpoint is independent of its Ctp1-dependent roles in double-strand break repair and checkpoint signaling.Semantic proximity Read ↗

The Mre11-Rad50-Nbs1 Complex Acts Both Upstream and Downstream of Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR) to Regulate the S-phase Checkpoint following UV TreatmentSemantic proximity Read ↗

A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast.Semantic proximity Read ↗

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MRX (Mre11/Rad50/Xrs2) mutants reveal dual intra-S-phase checkpoint systems in budding yeast.Semantic proximity Read ↗

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Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.Semantic proximity Read ↗

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MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaksSemantic proximity Read ↗

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