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A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair.

Nucleic acids research - 1 Apr 2010

Steininger Sylvia, Ahne Fred, Winkler Klaudia, Kleinschmidt Anja, Eckardt-Schupp Friederike, Moertl Simone

Abstract excerpt

The Mre11/Rad50/Xrs2 (MRX) complex in Saccharomyces cerevisiae has well-characterized functions in DNA double-strand break processing, checkpoint activation, telomere length maintenance and meiosis. In this study, we demonstrate an involvement of the complex in the base excision repair (BER) pathway. We studied the repair of methyl-methanesulfonate-induced heat-labile sites in chromosomal DNA in vivo and the in...

Topics

DNA Repair
DNA-Binding Proteins
Endodeoxyribonucleases
Epistasis, Genetic
Exodeoxyribonucleases
Gene Deletion
Hot Temperature
Methyl Methanesulfonate
Mutation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20040573
DOI: 10.1093/nar/gkp1175
PMCID: PMC2847237

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A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair.PMID 20040573Read ↗

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