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Article

A NOS-III haplotype that includes functional polymorphisms is associated with bipolar disorder.

The international journal of neuropsychopharmacology - 1 Feb 2006

Reif Andreas, Strobel Alexander, Jacob Christian P, Herterich Sabine, Freitag Christine M, Töpner Theresia, Mössner Rainald, Fritzen Sabrina, Schmitt Angelika, Lesch Klaus-Peter

Abstract excerpt

The pleiotropic messenger molecule nitric oxide (NO) has been implicated in a variety of higher CNS functions, including learning, memory, and emotionality. In the human brain, NO is predominantly formed by neuronal NO synthase (NOS-I), while the so-called 'endothelial' isoform NOS-III also contributes to NO generation. We recently reported that NOS-III knockout mice display decreased adult neurogenesis and...

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Share to Bipolar Disorder
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 15967063
DOI: 10.1017/S1461145705005560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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