Article
A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function.
Molecular psychiatry - 1 Mar 2006
Reif A, Herterich S, Strobel A, Ehlis A-C, Saur D, Jacob C P, Wienker T, Töpner T, Fritzen S, Walter U, Schmitt A, Fallgatter A J, Lesch K-P
Abstract excerpt
Nitric oxide (NO) is a gaseous neurotransmitter thought to play important roles in several behavioral domains. On a neurobiological level, NO acts as the second messenger of the N-methyl-D-aspartate receptor and interacts with both the dopaminergic as well as the serotonergic system. Thus, NO is a promising candidate molecule in the pathogenesis of endogenous psychoses and a potential target in their treatment....
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