Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial nitric oxide synthase gene haplotypes and circulating nitric oxide levels significantly associate with risk of essential hypertension.

Free radical biology & medicine - 1 Jun 2008

Nejatizadeh Azim, Kumar Rahul, Stobdan Tsering, Goyal A K, Sikdar Sunandan, Gupta Mohit, Javed Saleem, Pasha M A Qadar

Abstract excerpt

Nitric oxide (NO), a potent vasodilator, plays a pivotal role in blood pressure regulation. Endothelial NO synthase gene (NOS3) polymorphisms influence NO levels. Here, we investigated the role of the -922A/G, -786T/C, 4b/4a, and 894G/T polymorphisms of the NOS3 and NO(x) levels in 800 consecutiv...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Haplotypes
Share to Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nitric Oxide

Share to Nitric Oxide Synthase Type III

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Source

Identifiers

PMID: 18325347
DOI: 10.1016/j.freeradbiomed.2008.02.004

Genes

NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18325347-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial nitric oxide synthase gene haplotypes and circulating nitric oxide levels significantly associate with risk of essential hypertension.PMID 18325347Read ↗

Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms.Semantic proximity Read ↗

Influence of eNOS haplotypes on the plasma nitric oxide products concentrations in hypertensive and type 2 diabetes mellitus patients.Semantic proximity Read ↗

Contribution of NOS3AS Variants to Susceptibility to Essential Hypertension: A Study in Kermanshah Province, Western Iran.Semantic proximity Read ↗

Genetic and environmental determinants of plasma nitrogen oxides and risk of ischemic heart disease.Semantic proximity Read ↗

Clinically relevant endothelial nitric oxide synthase polymorphisms and their impact on drug response.Semantic proximity Read ↗

Functional polymorphisms of NOS3 and GUCY1A3 affect both nitric oxide formation and association with hypertensive disorders of pregnancySemantic proximity Read ↗

Endothelial nitric oxide synthase gene haplotypes associated with circulating concentrations of nitric oxide products in healthy menSemantic proximity Read ↗

Multi-locus interactions of vascular homeostasis genes in essential hypertension: a gender-based study.Semantic proximity Read ↗

The Role of Inducible NOS2 Gene Polymorphism in the Development of Essential Arterial Hypertension.Semantic proximity Read ↗

Endothelial nitric oxide synthase gene polymorphisms in cardiovascular disease.Semantic proximity Read ↗

Association study of the endothelial nitric oxide synthase gene polymorphisms with essential hypertension in northern Han ChineseSemantic proximity Read ↗

The interaction of AGT and NOS3 gene polymorphisms with conventional risk factors increases predisposition to hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.