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Article

Endothelial nitric oxide synthase gene haplotypes and circulating nitric oxide levels significantly associate with risk of essential hypertension.

Free radical biology & medicine - 1 Jun 2008

Nejatizadeh Azim, Kumar Rahul, Stobdan Tsering, Goyal A K, Sikdar Sunandan, Gupta Mohit, Javed Saleem, Pasha M A Qadar

Abstract excerpt

Nitric oxide (NO), a potent vasodilator, plays a pivotal role in blood pressure regulation. Endothelial NO synthase gene (NOS3) polymorphisms influence NO levels. Here, we investigated the role of the -922A/G, -786T/C, 4b/4a, and 894G/T polymorphisms of the NOS3 and NO(x) levels in 800 consecutive unrelated subjects comprising 455 patients of essential hypertension and 345 controls. The polymorphisms were...

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Source

Identifiers

PMID: 18325347
DOI: 10.1016/j.freeradbiomed.2008.02.004

Genes

NOS3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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