Article
Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and tardive dyskinesia in patients with schizophrenia.
Pharmacogenetics and genomics - 1 Mar 2006
Liou Ying-Jay, Lai I-Ching, Lin Ming-Wei, Bai Ya-Mei, Lin Chao-Cheng, Liao Ding-Lieh, Chen Jen-Yeu, Lin Chih-Yuan, Wang Ying-Chieh
Abstract excerpt
OBJECTIVES: Several studies have indicated the involvement of nitric oxide (NO) in the pathogenesis of tardive dyskinesia (TD), an incapacitating adverse movement disorder associated with long-term antipsychotic treatment. In human brain, the NO could be generated by endothelial nitric oxide synthase (NOS3). In this study, we studied whether the genetic variants in human NOS3 gene is associated with TD in...
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