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Uncovering associations between mental illness diagnosis, nitric oxide synthase gene variation, and peripheral nitric oxide concentration.

Brain, behavior, and immunity - 1 Mar 2022

McNeill Rhiannon V, Kehrwald Christopher, Brum Murielle, Knopf Katrin, Brunkhorst-Kanaan Nathalie, Etyemez Semra, Koreny Carolin, Bittner Robert A, Freudenberg Florian, Herterich Sabine, Reif Andreas, Kittel-Schneider Sarah

Abstract excerpt

Nitric oxide (NO) signalling has been implicated in the pathogenesis of several mental illnesses; however, its specific contribution remains unclear. We investigated whether peripheral NO concentration is associated with specific diagnoses, and whether there is a correlation with genetic variation in NO synthase (NOS) genes. We included 185 participants in the study; 52 healthy controls, 43 major depressive...

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Share to Adaptor Proteins, Signal Transducing
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nitric Oxide Synthase Type I

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Source

Identifiers

PMID: 35041938
DOI: 10.1016/j.bbi.2022.01.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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