Article
NOS-I and -III gene variants are differentially associated with facets of suicidal behavior and aggression-related traits.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2008
Rujescu Dan, Giegling Ina, Mandelli Laura, Schneider Barbara, Hartmann Annette M, Schnabel Axel, Maurer Konrad, Möller Hans-Jürgen, Serretti Alessandro
Abstract excerpt
Nitric oxide (NO) is a neurotransmitter which modulates depressive and aggressive behaviors. We studied gene variants of NOS-I (rs2682826;rs1353939;rs2293049;rs693534) and NOS-III (rs2070744;;) in a total of 571 cases (167 German suicide attempters, 92 Caucasian suicide completers and 312 German healthy subjects). A NOS-I risk haplotype C-G-G (--) was associated with...
