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Article

The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2005

Pandey Kailash C, Wang Stephanie X, Sijwali Puran S, Lau Anthony L, McKerrow James H, Rosenthal Philip J

Abstract excerpt

Falcipain-2 (FP2) is a papain family cysteine protease and important hemoglobinase of erythrocytic Plasmodium falciparum parasites. Inhibitors of FP2 block hemoglobin hydrolysis and parasite development, suggesting that this enzyme is a promising target for antimalarial chemotherapy. FP2 and rela...

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Identifiers

PMID: 15964982
DOI: 10.1073/pnas.0502368102
PMCID: PMC1166610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-15964982-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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