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Article

Crystal structure of a Trypanosoma brucei metacaspase.

Proceedings of the National Academy of Sciences of the United States of America - 8 May 2012

McLuskey Karen, Rudolf Jana, Proto William R, Isaacs Neil W, Coombs Graham H, Moss Catherine X, Mottram Jeremy C

Abstract excerpt

Metacaspases are distantly related caspase-family cysteine peptidases implicated in programmed cell death in plants and lower eukaryotes. They differ significantly from caspases because they are calcium-activated, arginine-specific peptidases that do not require processing or dimerization for activity. To elucidate the basis of these differences and to determine the impact they might have on the control of cell...

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Source

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Identifiers

PMID: 22529389
DOI: 10.1073/pnas.1200885109
PMCID: PMC3358904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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