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Article

Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association With Artemisinin Resistance.

The Journal of infectious diseases - 2 Jul 2018

Siddiqui Faiza A, Cabrera Mynthia, Wang Meilian, Brashear Awtum, Kemirembe Karen, Wang Zenglei, Miao Jun, Chookajorn Thanat, Yang Zhaoqing, Cao Yaming, Dong Gang, Rosenthal Philip J, Cui Liwang

Abstract excerpt

Background: Falcipain-2a ([FP2a] PF3D7_1115700) is a Plasmodium falciparum cysteine protease and hemoglobinase. Functional FP2a is required for potent activity of artemisinin, and in vitro selection for artemisinin resistance selected for an FP2a nonsense mutation. Methods: To investigate associations between FP2a polymorphisms and artemisinin resistance and to characterize the diversity of the enzyme in...

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PMID: 29659945
DOI: 10.1093/infdis/jiy188
PMCID: PMC6048984

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