Article
The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.
The Journal of biological chemistry - 19 Oct 2007
Teuscher Franka, Lowther Jonathan, Skinner-Adams Tina S, Spielmann Tobias, Dixon Matthew W A, Stack Colin M, Donnelly Sheila, Mucha Artur, Kafarski Paweł, Vassiliou Stamatia, Gardiner Donald L, Dalton John P, Trenholme Katharine R
Abstract excerpt
A member of the M18 family of aspartyl aminopeptidases is expressed by all intra-erythrocytic stages of the human malaria parasite Plasmodium falciparum (PfM18AAP), with highest expression levels in rings. Functionally active recombinant enzyme, rPfM18AAP, and native enzyme in cytosolic extracts of malaria parasites are 560-kDa octomers that exhibit optimal activity at neutral pH and require the presence of metal...
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