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Dissecting The role of Plasmodium metacaspase-2 in malaria gametogenesis and sporogony

10 Mar 2022

Abstract excerpt

The family of apicomplexan specific proteins contains caspases–like proteins called “metacaspases”. These enzymes are present in the malaria parasite but absent in human; therefore, these can be explored as potential drug targets. We deleted the MCA-2 gene from Plasmodium berghei genome using a gene knockout strategy to decipher its precise function. This study has identified that MCA-2 plays an important role in...

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PMID: 35264080
DOI: 10.1080/22221751.2022.2052357

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