Transcription promotes guanine to thymine mutations in the non-transcribed strand of an Escherichia coli gene.

doi:10.1016/j.dnarep.2005.04.017

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Article

Transcription promotes guanine to thymine mutations in the non-transcribed strand of an Escherichia coli gene.

DNA repair - 12 Jul 2005

Klapacz Joanna, Bhagwat Ashok S

Abstract excerpt

Transcription of DNA opens the chromatin, causes topological changes in DNA and transiently exposes the two strands to different biochemical environments. Consequently, it has long been argued that transcription may promote damage to DNA and there are data in Escherichia coli and yeast supporting a correlation between high transcription and mutations. We examined the transcription-dependence of the reversion of a...

Topics

Codon, Nonsense
DNA Glycosylases
DNA Repair
DNA-Formamidopyrimidine Glycosylase
Escherichia coli
Escherichia coli Proteins
Genes, Bacterial
Guanine
Mutagenesis
Mutation
Thymine
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 15961353
DOI: 10.1016/j.dnarep.2005.04.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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