Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA Replication-Transcription Conflicts Do Not Significantly Contribute to Spontaneous Mutations Due to Replication Errors in Escherichia coli.

mBio - 26 Oct 2021

Foster Patricia L, Niccum Brittany A, Lee Heewook

Abstract excerpt

Encounters between DNA replication and transcription can cause genomic disruption, particularly when the two meet head-on. Whether these conflicts produce point mutations is debated. This paper presents detailed analyses of a large collection of mutations generated during mutation accumulation experiments with mismatch repair (MMR)-defective Escherichia coli. With MMR absent, mutations are primarily due to DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mismatch Repair
Share to DNA Replication
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Frameshift Mutation

Share to Genome, Bacterial

Share to Mutation Rate

Share to Point Mutation

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 34634932
DOI: 10.1128/mBio.02503-21
PMCID: PMC8510543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA Replication-Transcription Conflicts Do Not Significantly Contribute to Spontaneous Mutations Due to Replication Errors in Escherichia coli.PMID 34634932Read ↗

The nature of mutations induced by replication–transcription collisions.Semantic proximity Read ↗

Oxygen and RNA in stress-induced mutation.Semantic proximity Read ↗

Oxidative stress drives mutagenesis through transcription coupled repair in bacteriaSemantic proximity Read ↗

Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing.Semantic proximity Read ↗

Adaptive mutation and amplification in Escherichia coli: two pathways of genome adaptation under stress.Semantic proximity Read ↗

Detection of DNA replication errors and 8-oxo-dGTP-mediated mutations in E. coli by Duplex DNA Sequencing.Semantic proximity Read ↗

Encoded errors: mutations and rearrangements mediated by misalignment at repetitive DNA sequences.Semantic proximity Read ↗

Universally high transcript error rates in bacteria.Semantic proximity Read ↗

Extended sequence context shapes mutational bias in Escherichia coli.Semantic proximity Read ↗

Spontaneous mutation in Escherichia coli containing the dnaE911 DNA polymerase antimutator allele.Semantic proximity Read ↗

Heterogeneity of spontaneous DNA replication errors in single isogenic Escherichia coli cells.Semantic proximity Read ↗

Insights into mutagenesis using Escherichia coli chromosomal lacZ strains that enable detection of a wide spectrum of mutational events.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.