Article
Transcription-associated mutagenesis increases protein sequence diversity more effectively than does random mutagenesis in Escherichia coli.
PloS one - 10 May 2010
Kim Hyunchul, Lee Baek-Seok, Tomita Masaru, Kanai Akio
Abstract excerpt
BACKGROUND: During transcription, the nontranscribed DNA strand becomes single-stranded DNA (ssDNA), which can form secondary structures. Unpaired bases in the ssDNA are less protected from mutagens and hence experience more mutations than do paired bases. These mutations are called transcription-associated mutations. Transcription-associated mutagenesis is increased under stress and depends on the DNA sequence....
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