Article
Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy - 1 Jul 1998
Williams D L, Spring L, Collins L, Miller L P, Heifets L B, Gangadharam P R, Gillis T P
Abstract excerpt
The contributions of 23 insertion, deletion, or missense mutations within an 81-bp fragment of rpoB, the gene encoding the beta-subunit of the DNA-dependent RNA polymerase of Mycobacterium tuberculosis, to the development of resistance to rifamycins (rifampin, rifabutin, rifapentine, and KRM-1648...
Topics
- Anti-Bacterial Agents
- Base Sequence
- DNA, Bacterial
- DNA-Directed RNA Polymerases
- Drug Resistance, Microbial
- Molecular Sequence Data
- Mutation
- Mycobacterium tuberculosis
- Rifamycins