Article
Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis.
Lancet (London, England) - 13 Mar 1993
Telenti A, Imboden P, Marchesi F, Lowrie D, Cole S, Colston M J, Matter L, Schopfer K, Bodmer T
Abstract excerpt
Control of tuberculosis is threatened by widespread emergence of drug resistance in Mycobacterium tuberculosis. Understanding the molecular basis of resistance might lead to development of novel rapid methods for diagnosing drug resistance. We set out to determine the molecular basis of resistance to rifampicin, a major component of multidrug regimens used for treating tuberculosis. Resistance to rifampicin...
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