Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin.

BMC microbiology - 15 Jan 2009

Zaczek Anna, Brzostek Anna, Augustynowicz-Kopec Ewa, Zwolska Zofia, Dziadek Jaroslaw

Abstract excerpt

BACKGROUND: Rifampin is a first line antituberculosis drug active against bacilli in logarithmic and stationary phase, which interferes with RNA synthesis by binding to bacterial RNA polymerase. Tubercle bacilli achieve resistance to rifampin by accumulation of mutations in a short-81 bp region of the rpoB gene. Among many mutations identified in the rpoB gene, few were verified by molecular genetic methods as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Antitubercular Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Bacterial

Share to DNA-Directed RNA Polymerases

Share to Drug Resistance, Bacterial

Share to Microbial Sensitivity Tests

Share to Mycobacterium tuberculosis

Share to Rifampin

Source

Open in PubMed Open full text

Identifiers

PMID: 19146699
DOI: 10.1186/1471-2180-9-10
PMCID: PMC2652454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin.PMID 19146699Read ↗

Mutations of rpob Gene Associated with Rifampin Resistance among Mycobacterium Tuberculosis Isolated in Tuberculosis Regional Reference Laboratory in Northeast of Iran during 2015-2016.Semantic proximity Read ↗

Characterization of Mutations Conferring Resistance to Rifampin in Mycobacterium tuberculosis Clinical Strains.Semantic proximity Read ↗

rpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosisSemantic proximity Read ↗

Identification of mutations in the rpoB encoding the RNA polymerase beta subunit in rifampicine-resistant Mycobacterium tuberculosis strains from Iran.Semantic proximity Read ↗

Sequence analysis of rpoB mutations in rifampin-resistant clinical Mycobacterium tuberculosis isolates from Turkey.Semantic proximity Read ↗

Molecular analysis of rpoB gene mutation in MTB detected isolates in a tertiary care centre (AGMC) of North-East, India.Semantic proximity Read ↗

Characterization of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis isolates from the Middle East.Semantic proximity Read ↗

[Detection and characteristics of rpoB gene mutations in rifampicin-resistant clinical strains of M. tuberculosis].Semantic proximity Read ↗

rpoB Mutations are Associated with Variable Levels of Rifampin and Rifabutin Resistance in Mycobacterium tuberculosisSemantic proximity Read ↗

Characterization of rpoB gene mutations in rifampicin resistant Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients at 5 Mexican public hospitals.Semantic proximity Read ↗

rpoB mutations in multidrug-resistant strains of Mycobacterium tuberculosis isolated in Italy.Semantic proximity Read ↗

Rifampin Resistance Missed in Automated Liquid Culture System for Mycobacterium tuberculosis Isolates with Specific <i>rpoB</i> MutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.