Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Profiling of rpoB mutations and MICs for rifampin and rifabutin in Mycobacterium tuberculosis.

Journal of clinical microbiology - 1 Jun 2014

Jamieson F B, Guthrie J L, Neemuchwala A, Lastovetska O, Melano R G, Mehaffy C

Abstract excerpt

Resistance to rifampin (RIF) and rifabutin (RFB) in Mycobacterium tuberculosis is associated with mutations within an 81-bp region of the rpoB gene (RIF resistance-determining region [RRDR]). Previous studies have shown that certain mutations in this region are more likely to confer high levels of RIF resistance, while others may be found in phenotypically susceptible isolates. In this study, we sought to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed RNA Polymerases

Share to Genome, Bacterial

Share to Microbial Sensitivity Tests

Share to Mycobacterium tuberculosis

Share to Rifampin

Share to Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 24740074
DOI: 10.1128/JCM.00691-14
PMCID: PMC4042728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Profiling of rpoB mutations and MICs for rifampin and rifabutin in Mycobacterium tuberculosis.PMID 24740074Read ↗

rpoB Mutations are Associated with Variable Levels of Rifampin and Rifabutin Resistance in Mycobacterium tuberculosisSemantic proximity Read ↗

Rifampin resistance-associated mutations in the RIF resistance-determining region (RRDR) of the rpoB gene of Mycobacterium tuberculosis clinical isolates in Shanghai, ChinaSemantic proximity Read ↗

Association between the rifampicin resistance mutations and rifabutin susceptibility in Mycobacterium tuberculosis: A meta-analysis.Semantic proximity Read ↗

Rifampin-resistance-associated mutations in the rifampin-resistance-determining region of the rpoB gene of Mycobacterium tuberculosis clinical isolates in Shanghai, PR China.Semantic proximity Read ↗

Differential Impact of the rpoB Mutant on Rifampin and Rifabutin Resistance Signatures of Mycobacterium tuberculosis Is Revealed Using a Whole-Genome Sequencing Assay.Semantic proximity Read ↗

Characterization of Mutations Conferring Resistance to Rifampin in Mycobacterium tuberculosis Clinical Strains.Semantic proximity Read ↗

Frequency of genomic mutations mediating resistance of Mycobacterium tuberculosis isolates to rifampicin in Northern Morocco.Semantic proximity Read ↗

Characterization of Genetic Variants Associated with Rifampicin Resistance Level in Mycobacterium tuberculosis Clinical Isolates Collected in Guangzhou Chest Hospital, ChinaSemantic proximity Read ↗

rpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosisSemantic proximity Read ↗

Mutations in rpoB and katG genes of multidrug resistant mycobacterium tuberculosis undetectable using genotyping diagnostic methods.Semantic proximity Read ↗

Decoding antibiotic resistance in tuberculosis: Role of RRDR and non-RRDR mutations in diagnostic perspectives.Semantic proximity Read ↗

Low-Level Rifampin Resistance and rpoB Mutations in Mycobacterium tuberculosis: an Analysis of Whole-Genome Sequencing and Drug Susceptibility Test Data in New York.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.