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Article

Innate immune detection of flagellin positively and negatively regulates salmonella infection.

PloS one - 1 Jan 2013

Lai Marvin A, Quarles Ellen K, López-Yglesias Américo H, Zhao Xiaodan, Hajjar Adeline M, Smith Kelly D

Abstract excerpt

Salmonella enterica serovar Typhimurium is a flagellated bacterium and one of the leading causes of gastroenteritis in humans. Bacterial flagellin is required for motility and also a prime target of the innate immune system. Innate immune recognition of flagellin is mediated by at least two independent pathways, TLR5 and Naip5-Naip6/NlrC4/Caspase-1. The functional significance of each of the two independent...

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Source

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Identifiers

PMID: 23977202
DOI: 10.1371/journal.pone.0072047
PMCID: PMC3747147

Genes

TLR5

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