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Article

Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retention.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2005

Zhang Hui, Zhang Aihua, Kohan Donald E, Nelson Raoul D, Gonzalez Frank J, Yang Tianxin

Abstract excerpt

The peroxisome proliferator-activated receptor subtype gamma (PPARgamma) ligands, namely the synthetic insulin-sensitizing thiazolidinedione (TZD) compounds, have demonstrated great potential in the treatment of type II diabetes. However, their clinical applicability is limited by a common and serious side effect of edema. To address the mechanism of TZD-induced edema, we generated mice with collecting duct...

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Identifiers

PMID: 15956187
DOI: 10.1073/pnas.0501744102
PMCID: PMC1166599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retention.PMID 15956187Read ↗

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